Baseline tricuspid annular diameter independently predicted persistent ≥ moderate tricuspid regurgitation 12 months after transcatheter ASD closure (OR 4.53; 95% CI 2.26-9.10; P<0.001).
Observational (n=200)
No
Does transcatheter ASD closure improve functional tricuspid regurgitation and right heart remodeling in adults with secundum ASD?
Transcatheter ASD closure improves functional TR and right heart remodeling, but a baseline tricuspid annular diameter >39 mm strongly predicts persistent significant TR, suggesting these patients may benefit from surgical closure with annuloplasty.
Odds Ratio: 4.53 (95% CI 2.26–9.1)
p-value: p=<0.001
BACKGROUND: Functional tricuspid regurgitation (TR) is frequently present in adults with secundum atrial septal defect (ASD) due to chronic right-sided volume overload and right heart remodeling. AIMS: The aim of this study is to evaluate changes in TR severity, tricuspid annular and right ventricular (RV) reverse remodeling 12 months after transcatheter ASD closure, including RV systolic function assessed by conventional parameters and RV free wall longitudinal strain (RVFWLS). We also evaluated baseline echocardiographic predictors of persistent ≥ moderate TR at follow-up. METHODS: We prospectively enrolled 200 adult patients (150 women, 50 men) with the median age of 35 years (interquartile range 25.0-48.5) undergoing transcatheter closure of secundum ASD. Transthoracic echocardiography was performed before the procedure and at 12-month follow-up to assess TR severity, RV and tricuspid annular dimensions and RV systolic function, including RVFWLS. Persistent TR was defined as ≥ moderate TR at 12 months. Baseline predictors of persistent TR were evaluated using univariate and multivariable logistic regression analyses. RESULTS: The severity of TR was reduced after 12 months (P 39 mm identifies patients at increased odds of persistent significant TR after device closure and may support consideration of surgical ASD closure with concomitant tricuspid annuloplasty.
Sachajko et al. (Tue,) conducted a observational in Secundum atrial septal defect (n=200). Baseline tricuspid annular diameter was evaluated on Persistent ≥ moderate tricuspid regurgitation at 12 months (OR 4.53, 95% CI 2.26-9.10, p=<0.001). Baseline tricuspid annular diameter independently predicted persistent ≥ moderate tricuspid regurgitation 12 months after transcatheter ASD closure (OR 4.53; 95% CI 2.26-9.10; P<0.001).
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