Key result
ASD closure and pulmonic valve replacement significantly reduced moderate or severe tricuspid regurgitation from 23.5% preoperatively to 12.3% at 12 months (p<0.0001).
Why the study?
Little was known about the effect of cardiac surgery or catheter interventions to reduce right ventricular volume loading on pre-existing tricuspid regurgitation in adults with congenital heart disease.
Does atrial septal defect closure or pulmonic valve replacement reduce the severity of pre-existing tricuspid regurgitation in adults with congenital heart disease?
Population
162 consecutive patients with at least mild preoperative TR undergoing ASD closure or PVR at a single centre
Comparison
ASD closure vs PVR, with or without concomitant tricuspid valve surgery
Design
Single-centre observational cohort study
Follow-up
12 months
Authors
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TR reduction after ASD closure or PVR may occur in ACHD; leaves open predictors of residual TR and needs prospective confirmation.
Cohort (n=162)
No
Does atrial septal defect closure or pulmonic valve replacement reduce the severity of pre-existing tricuspid regurgitation in adults with congenital heart disease?
Absolute Event Rate: 12.3% vs 23.5%
p-value: p=<0.0001
ASD closure and PVR significantly reduce pre-existing tricuspid regurgitation severity in adults with congenital heart disease, even without concomitant tricuspid valve surgery.
Martín‐García et al. (2019) conducted a cohort in Atrial septal defect or pulmonic valve replacement with pre-existing tricuspid regurgitation (n=162). Atrial septal defect closure or pulmonic valve replacement vs. Preoperative baseline was evaluated on Moderate or severe tricuspid regurgitation (p=<0.0001). ASD closure and pulmonic valve replacement significantly reduced moderate or severe tricuspid regurgitation from 23.5% preoperatively to 12.3% at 12 months (p<0.0001).
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