Why the study?
Does a valve syndrome framework (AVS, PVS, SVS) predict the composite of death or heart failure hospitalization in patients with severe aortic stenosis?
Cohort (n=2,824)
Does a valve syndrome framework (AVS, PVS, SVS) predict the composite of death or heart failure hospitalization in patients with severe aortic stenosis?
Hazard Ratio: 2.34 (95% CI 1.19–4.59)
p-value: p=0.01
A valve syndrome framework incorporating symptoms, natriuretic peptides, and LVEF refines risk stratification in severe aortic stenosis beyond symptom status alone.
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Mandava et al. (2026) conducted a cohort in Severe aortic stenosis (n=2,824). Acute valve syndrome (AVS) vs. Stable valve syndrome (SVS) was evaluated on Composite of death or heart failure hospitalization (HR 2.34, 95% CI 1.19-4.59, p=0.01).
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