GLP-1 agonist use before endovascular thrombectomy for acute ischemic stroke was associated with lower mortality (11.5% vs 29.9%; HR 0.334) and fewer hospitalizations (HR 0.514, p<0.001).
Does GLP-1 receptor agonist exposure prior to endovascular thrombectomy reduce mortality and hospitalizations in adults with acute ischemic stroke?
Pre-stroke exposure to GLP-1 receptor agonists is associated with significantly improved 3-year survival and reduced hospitalizations following endovascular thrombectomy for acute ischemic stroke.
Absolute Event Rate: 0% vs 0%
BACKGROUND Glucagon-like peptide-1 receptor agonists (GLP-1As) have demonstrated cardiovascular and cerebrovascular benefits in high-risk populations, but their impact in patients with acute ischemic stroke (AIS) requiring endovascular thrombectomy (EVT) remains uncertain. METHODS We performed a retrospective cohort analysis using the TriNetX Network, identifying adults (≥18 years) with AIS treated with EVT from January 1, 2016 through December 31, 2025. Patients with GLP-1A exposure within three months prior to EVT constituted the exposure cohort; those without served as comparators. This pre-index window was specified to eliminate immortal time bias, with follow-up beginning on the EVT date for both cohorts. Three-year outcomes included all-cause mortality and inpatient hospitalizations. One-to-one propensity score matching was applied using demographic, comorbidity, medication, and metabolic variables including individual National Institute of Health Stroke Scale scores, Hemoglobin A1c, and body mass index. RESULTS Among 286 GLP-1A-exposed and 19,263 unexposed EVT-treated patients, 261 matched pairs were analyzed. GLP-1A use was associated with lower all-cause mortality (11.5% vs 29.9%; HR 0.334, 95% CI 0.219-0.508) and fewer inpatient hospitalizations (39.8% vs 54.8%; HR 0.514, 95% CI 0.398-0.663), both p < 0.001. CONCLUSIONS Among EVT-treated AIS patients, GLP-1A exposure within three months prior to EVT was associated with improved survival and reduced inpatient hospitalizations.
Rai et al. (Sat,) reported a other. GLP-1 agonist use before endovascular thrombectomy for acute ischemic stroke was associated with lower mortality (11.5% vs 29.9%; HR 0.334) and fewer hospitalizations (HR 0.514, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: