Key result
IMPLEMENT-HF increases defect-free quadruple medical therapy at discharge to ~45% in heart failure patients.
Why the study?
Despite class 1 recommendations showing survival benefit, quadruple medical therapy for heart failure with reduced ejection fraction remains underutilized.
Does a multiregional quality improvement learning collaborative initiative improve the utilization of guideline-directed quadruple medical therapy in patients hospitalized with heart failure with reduced ejection fraction?
Observational (n=43,558)
Yes
Does a multiregional quality improvement learning collaborative initiative improve the utilization of guideline-directed quadruple medical therapy in patients hospitalized with heart failure with reduced ejection fraction?
A multiregional quality improvement initiative significantly increased the prescription of guideline-directed quadruple medical therapy and the assessment of health-related social needs for patients hospitalized with HFrEF.
May support QMT optimization via quality initiatives in HFrEF; leaves open causal outcome benefits pending randomized confirmation.
BACKGROUND: Despite randomized data for survival benefit (with class 1 recommendations) for treating heart failure (HF) with reduced ejection fraction using quadruple medical therapy (QMT)-defined as evidence-based β-blockers, sodium-glucose cotransporter 2 inhibitor, preferably angiotensin receptor/neprilysin inhibitor, and mineralocorticoid receptor antagonist-it is underutilized. IMPLEMENT-HF is a multiregional HF quality improvement initiative to improve care and outcomes for patients with HF by enhancing the use of QMT in routine practice. METHODS: This analysis of HF with reduced ejection fraction treatment in patients from hospitals participating in the American Heart Association's Get With The Guidelines-HF who volunteered to participate in IMPLEMENT-HF in 7 US regions. IMPLEMENT-HF included multidisciplinary learning to share strategies for formulary changes, electronic health record tools, and patient resources with site-level feedback reports. Participants gathered QMT data at discharge and 30 days after discharge. We evaluated QMT utilization and variation, in addition to other prespecified performance measures, from Q1 2021 to Q2 2023. There was also substantially improved incorporation of health-related social needs assessments. The magnitude of improvements was similar when stratified by sex or race and ethnicity, yet there was significant regional variation. CONCLUSIONS: Among healthcare systems participating in IMPLEMENT-HF, there was a marked increase in QMT use among eligible patients over the course of the initiative. This quality improvement initiative supports a learning collaborative model to promote improvements in QMT use.
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Sauer et al. (2025) conducted an observational in Heart failure with reduced ejection fraction (n=43,558). IMPLEMENT-HF quality improvement initiative vs. Baseline (Q1 2021) was evaluated on Defect-free quadruple medical therapy (QMT) at discharge (p=<0.0001). The IMPLEMENT-HF quality improvement initiative significantly increased the use of defect-free quadruple medical therapy at discharge from 4.7% to 44.6% among eligible patients with heart failure.
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