What question did this study set out to answer?

The study aims to determine the role of IL-12Rβ2 in assessing vascular smooth muscle cell activation during acute myocardial infarction.

June 25, 2026Korean Circulation Journal0 citationsOpen Access

IL-12Rβ2 is Expressed in the Synthetic SMC and Detected in the Blood of Patients With Acute Myocardial Infarction

DKDong Hoon Kang HLHee Su Lee JYJin-Ah Yang

Key Points

The study aims to determine the role of IL-12Rβ2 in assessing vascular smooth muscle cell activation during acute myocardial infarction.
Identification of IL-12Rβ2 expression in synthetic smooth muscle cells upon interferon-γ stimulation.

Structured PICO

Is circulating IL-12Rβ2 elevated in patients with acute myocardial infarction as a biomarker of SMC activation?

Population

Patients with acute myocardial infarction (AMI) and synthetic smooth muscle cells (SMCs)

Intervention

Measurement of circulating IL-12Rβ2 using a novel capture enzyme-linked immunosorbent assay

Outcome

Circulating IL-12Rβ2 levelssurrogate

IL-12Rβ2 is a novel non-invasive biomarker that reflects SMC-driven plaque instability and is elevated in patients with acute myocardial infarction.

Abstract

Current cardiac biomarkers fail to detect vascular smooth muscle cell (SMC) activation, a key feature of vulnerable plaque formation in acute myocardial infarction (AMI).This study identifies interleukin-12 receptor beta 2 subunit (IL-12Rβ2) as a receptor selectively expressed in synthetic SMCs upon interferon-γ stimulation and released via SMC-derived extracellular vesicles.Circulating IL-12Rβ2 was significantly elevated in AMI patients and detected using a novel capture enzyme-linked immunosorbent assay.These findings suggest IL-12Rβ2 as a non-invasive biomarker reflecting SMC-driven plaque instability, offering a novel diagnostic strategy for early risk stratification in coronary artery disease.

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