Plasma Concentrations of Interleukin-2 Soluble Receptor in Mild Ischaemic Left Ventricular Dysfunction
Population
40 consecutive patients referred to the catheterization laboratory for left ventricle and coronary…
Design
Cross-sectional
Authors
Discussion
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Implication
Elevated sIL-2R associates with reduced LVEF; hypothesis-generating for T-cell activation and requires prospective validation before any clinical role.
Key Points
- To assess whether inflammatory and immune system activation, specifically measured by CRP, IL-1Ra, and sIL-2R, occurs in patients during the early phases of mild ischaemic left ventricular dysfunction.
- Enrolled 40 consecutive patients undergoing coronary and left ventricular angiography for suspected coronary artery disease (median age 61 years, 6 females).
- Measured pre-catheterization plasma levels of CRP, IL-1Ra, and sIL-2R via ELISA and determined left ventricular ejection fraction via quantitative angiography, classifying mild-to-moderate dysfunction as LVEF ≤50% (n=13).
- Analyzed correlations between biomarker levels, patient demographics, and angiographic indices using Mann-Whitney U, Spearman rank, and multivariate regression tests.
- Plasma sIL-2R levels were significantly higher in patients with left ventricular dysfunction compared to those with preserved function (median 1605 vs. 1183 pg/ml; P=0.03), whereas CRP and IL-1Ra levels did not differ.
- Plasma sIL-2R negatively correlated with LVEF (R=-0.30, P=0.03 overall; R=-0.60, P=0.005 in patients aged ≤60 years) and remained significantly correlated in multivariate analysis (P=0.01).
- Patients with sIL-2R levels above the median had a significantly higher prevalence of left ventricular dysfunction compared to those below the median (53% vs. 17%; RR 3.68, 95% CI 1.19–11.42; P=0.024).
Structured PICO
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Population
40 consecutive patients referred to the catheterization laboratory for left ventricle and coronary angiography with suspected coronary artery disease and confirmed significant CAD, median age 61 years, 6 females. 22 (55%) had a history of previous myocardial infarction.
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Outcome
Plasma levels of C-reactive protein (CRP), Interleukin-1 receptor antagonist (IL-1Ra), and Interleukin-2 soluble receptor (sIL-2R)surrogate
Elevated plasma levels of soluble IL-2 receptor in patients with mild ischemic left ventricular dysfunction suggest early T-lymphocyte activation in this condition.
Cite This Study
Abbate et al. (2003) studied this question.