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June 27, 2026CancersOpen Access

Diagnostic Considerations for Neurolymphomatosis: A Natural History Analysis

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Authors

FRFrancesca RothellMNMary Ann NguyenEXElizabeth Xu

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Overview

Natural history analysis defines optimal diagnostic strategies for neurolymphomatosis, suggesting improved outcomes with biopsy.

Key Points

  • This study aims to identify the best diagnostic methods for neurolymphomatosis and their association with patient outcomes.
  • Analyzed 559 neurolymphomatosis cases from 231 articles published from 1951 to 2022
  • Examined correlations between patient outcomes and various diagnostic modalities
  • Utilized separate analyses to reduce confounding from multiple diagnostic tools.
  • Patients with biopsies showed longer intervals from first treatment to progression (p<0.0001) and higher overall survival (p<0.0001)
  • Combination of biopsy with PET, MRI, and EMG-NCS showed positive trends for patient outcomes
  • No significant correlation of outcomes was found in the non-biopsied population.

Cite This Study

Rothell et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f92ahttps://doi.org/10.3390/cancers18132068
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Spectrum, Diagnostic Work-up, and Outcomes of Neurolymphomatosis in Lymphoid Malignancies: A 10-Patient Case Series2026
  2. 2The role of 18F-FDG PET/CT in Neurolymphomatosis: A Comprehensive Imaging Approach2024
  3. 3Prognostic factors and therapeutic outcomes in neurolymphomatosis: A 22-year cohort study from Mayo Clinic2025
  4. 4Recurrence of B-cell Lymphoma Manifesting as Progressive Peripheral and Cranial Nerve Neuropathies: A Case Report2026
  5. 5The paraneurium and the tumefactive appearance of peripheral nerve neurolymphomatosis: illustrative case2024 · 3 citations