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December 8, 2025Blood

Prognostic factors and therapeutic outcomes in neurolymphomatosis: A 22-year cohort study from Mayo Clinic

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Authors

OAOluwatayo AdeoyeARAllison RosenthalDLDaniel H. Lachance

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Overview

Cohort study reveals impact of primary NL and ASCT on treatment response in lymphoma-associated neurolymphomatosis.

Key Points

  • This research aimed to evaluate prognostic factors and treatment outcomes in patients with neurolymphomatosis at Mayo Clinic.
  • Retrospective analysis of patients diagnosed with neurolymphomatosis from 2002 to 2024
  • Comparison of baseline characteristics and survival outcomes using statistical tests
  • Assessment of treatment regimens and response rates
  • Median overall survival was 56 months with a 5-year OS of 50%
  • Primary neurolymphomatosis linked to improved response rates and survival
  • Frontline autologous stem cell transplant led to significantly prolonged progression-free survival

Cite This Study

Adeoye et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d53fhttps://doi.org/10.1182/blood-2025-6306
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Spectrum, Diagnostic Work-up, and Outcomes of Neurolymphomatosis in Lymphoid Malignancies: A 10-Patient Case Series2026
  2. 2Patient characteristics, treatment patterns, and outcomes in primary CNS lymphoma of T-cell origin: A multi-institution retrospective analysis2025
  3. 3Diagnostic Considerations for Neurolymphomatosis: A Natural History Analysis2026
  4. 4Early-stage nodular lymphocyte predominant Hodgkin lymphoma: Disease characteristics, treatment pattern, and long-term outcomes from a tertiary care cancer institute in India2025
  5. 5Real-world treatment patterns and survival outcomes in primary CNS lymphoma: Analysis of the national cancer database2025 · 1 citations