What question did this study set out to answer?

This study aims to characterize the phytochemical composition of mango pulp and evaluate its effects on metabolic and immune functions in diabetic and hypertensive rats.

June 27, 2026International Journal of Molecular SciencesOpen Access

Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models

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Authors

WTWachiraporn TipsuwanUniversity of Phayao HTHathairat ThananchaiChiang Mai University APAnusara PongjantaChiang Rai Rajabhat University

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Implication

Randomized trial examines the effects of mango pulp extract on metabolic, cardiovascular, and immune functions in diabetic and hypertensive rat models, suggesting potential therapies.

Key Points

This study aims to characterize the phytochemical composition of mango pulp and evaluate its effects on metabolic and immune functions in diabetic and hypertensive rats.
Rats with streptozotocin-induced diabetes and L-NAME-induced hypertension were used to evaluate the effects of mango pulp extract.
Key measures included plasma triglyceride and cholesterol levels, blood pressure, heart rate, and immune function variables like neutrophil phagocytosis.
Mango pulp extract was administered at doses of 300 mg/kg for diabetic rats and 400 mg/kg for hypertensive rats.
In diabetic rats, mango pulp extract reduced plasma triglyceride by 36.7% and total cholesterol by 45.3%, with modest antihyperglycemic effects (6.8%).
In hypertensive rats, extract administration produced a 42.7% reduction in blood pressure and a 53.5% reduction in heart rate.
Neutrophil phagocytic activity increased by 43% with significant effects observed at doses of 100-400 mg/kg.

Cite This Study

Tipsuwan et al. (2026) studied this question.

synapsesocial.com/papers/6a3f68a3aea7db3c1953fa81 https://doi.org/10.3390/ijms27135742

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Implication

Randomized trial examines the effects of mango pulp extract on metabolic, cardiovascular, and immune functions in diabetic and hypertensive rat models, suggesting potential therapies.

Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models

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Implication

Key Points

Cite This Study

Phytochemical Characterization and Immunometabolic Modulation by Mangifera indica (Mahajanaka) Pulp Extract in Diabetic and Hypertensive Rat Models

Discussion

Member takes

Implication

Key Points

Cite This Study

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