What question did this study set out to answer?

Assess the hypoperfusion intensity ratio as a predictive marker in acute middle cerebral artery occlusion associated with intracranial atherosclerosis.

June 27, 2026Cerebrovascular Diseases ExtraOpen Access

Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion MRI for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis

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Authors

YLYoonkyung Lee JCJae-Kwan Cha DKDae-Hyun Kim

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Implication

Randomized trial examines hypoperfusion intensity ratio's predictive value in acute ischemic stroke, suggesting improved diagnosis of underlying conditions.

Key Points

Assess the hypoperfusion intensity ratio as a predictive marker in acute middle cerebral artery occlusion associated with intracranial atherosclerosis.
Analyzed 117 patients with acute MCA occlusion using perfusion MRI before endovascular treatment (EVT).
Classified patients into intracranial atherosclerotic disease (ICAD) and non-ICAD groups and assessed clinical parameters with logistic regression.
Developed a machine learning algorithm using XGBoost to determine important features influencing ICAD.
34% of patients were in the ICAD group, showing higher levels of low-density lipoprotein cholesterol (LDL-C).
Inclusion of hypoperfusion intensity ratio improved predictive performance significantly (AUC 0.73 vs 0.88, p-value < 0.001).
XGBoost model achieved high accuracy (0.92) with identified important features including hypoperfusion intensity ratio and other clinical factors.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6922aea7db3c195400e0 https://doi.org/10.1159/000552144

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Implication

Randomized trial examines hypoperfusion intensity ratio's predictive value in acute ischemic stroke, suggesting improved diagnosis of underlying conditions.

Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion MRI for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis

Discussion

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Implication

Key Points

Cite This Study

Hypoperfusion Intensity Ratio as a Predictive Marker in Pre-Endovascular Treatment Perfusion MRI for Acute Middle Cerebral Artery Occlusion with Intracranial Atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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