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June 27, 2026Journal of Clinical MedicineOpen Access

Critical Prognostic and Predictive Factors in Colorectal Liver Metastasis: A Thorough Analysis of Existing Literature and Future Outlook

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Authors

PPPaul PascaIFIonuţ Flaviu FaurCBCosmin Burta

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Overview

Narrative analysis reveals factors affecting prognosis in colorectal cancer liver metastasis, suggesting personalized treatment approaches.

Key Points

  • The aim is to identify key prognostic and predictive factors in colorectal cancer with liver metastasis and assess future treatment implications.
  • Conducted a narrative review of literature from databases including PubMed, MEDLINE, Scopus, and Embase.
  • Focused on original articles published between 2005 and 2025.
  • Lymph node involvement correlates with a higher risk of liver metastasis and reduced survival.
  • Poorly differentiated tumors (G3) show higher metastatic likelihood and worse outcomes.
  • Genetic mutations (KRAS, NRAS, BRAF) lead to therapy resistance, emphasizing the need for personalized treatment.

Cite This Study

Pasca et al. (2026) studied this question.

synapsesocial.com/papers/6a3f694caea7db3c195401d6https://doi.org/10.3390/jcm15134907
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives2025
  2. 2A Comparative Study of Clinical and Molecular Features of Microsatellite Stable Colorectal Cancer With and Without Liver Metastases2025
  3. 3Key molecular mechanisms and regulatory networks in colorectal cancer liver metastasis2026
  4. 4Influence of Biomarkers on Mortality among Patients with Hepatic Metastasis of Colorectal Cancer Treated with FOLFOX/CAPOX and FOLFIRI/CAPIRI, Including Anti-EGFR and Anti-VEGF Therapies2024 · 8 citations
  5. 5Prognostic models and predictors of recurrence in resectable colorectal liver metastases: A systematic review and meta-analysis2026