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November 17, 2025CancersOpen Access

A Comparative Study of Clinical and Molecular Features of Microsatellite Stable Colorectal Cancer With and Without Liver Metastases

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Authors

TMTara MaggeSCSvea ChengSWShuaichao Wang

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Overview

Comparative study reveals liver metastasis reduces treatment response in metastatic CRC, indicating survival differences based on molecular data.

Key Points

  • This research compares clinical and molecular characteristics in colorectal cancer patients with and without liver metastasis.
  • Identified patients diagnosed with metastatic CRC from 2014 to 2022 using a molecular database
  • Collected demographic, clinical, and molecular data for analysis
  • Applied Fisher’s exact tests, Kaplan–Meier, and multivariate Cox regression for statistical analysis.
  • Higher incidence of liver metastasis in colon cancer (74%) compared to rectal cancer (48%)
  • No significant difference in common driver mutations (KRAS, BRAF, TP53) between metastasis groups
  • Liver metastasis is linked to shorter time on frontline therapy (13 months vs. 19.7 months)
  • KRAS mutations predicted worse survival in liver metastasis cohort only.

Cite This Study

Magge et al. (2025) studied this question.

synapsesocial.com/papers/692509f6c0ce034ddc352dd1https://doi.org/10.3390/cancers17223677
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Critical Prognostic and Predictive Factors in Colorectal Liver Metastasis: A Thorough Analysis of Existing Literature and Future Outlook2026
  2. 2Clinical, pathological and molecular insights in metastatic colorectal cancer with bone metastases: a retrospective study2024
  3. 3Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives2025 · 21 citations
  4. 4Comparison of gene mutations of liver metastases to the primary tumor in colorectal cancer: lessons from a small cohort2026
  5. 5Impact of Driver Genetic Alterations on Survival in Metastatic Colorectal Cancer Patients from a Genetically Homogeneous Sardinian Population: A Real-World Study2026