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September 10, 2025CancersOpen Access

Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives

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Authors

MCMaria ConticchioÉUÉmilie UldryMHMartin Hübner

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Overview

This review highlights prognostic factors influencing colorectal liver metastases management, suggesting novel biomarkers for personalized therapy.

Key Points

  • Molecular profiling is critical in guiding treatment decisions, affecting long-term survival in patients with colorectal liver metastases.
  • Key findings show that RAS/BRAF mutations can predict resistance to anti-EGFR therapies while MSI-H status suggests responsiveness to immunotherapy.
  • Current guidelines advocate for a personalized approach, yet standardizing criteria for resectability remains a significant challenge.
  • Emerging tools like circulating tumor DNA and insights from the gut microbiome hold promise for improving risk stratification and treatment efficacy.

Cite This Study

Conticchio et al. (2025) studied this question.

synapsesocial.com/papers/68c1a76954b1d3bfb60e04c7https://doi.org/10.3390/cancers17152539
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Critical Prognostic and Predictive Factors in Colorectal Liver Metastasis: A Thorough Analysis of Existing Literature and Future Outlook2026
  2. 2Molecular profiling and patient selection for the multimodal approaches for patients with resectable colorectal liver metastases2024 · 5 citations
  3. 3Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation2026
  4. 4Integration of Radical Intent Treatment in Colorectal Liver Metastases2025
  5. 5Prognostic models and predictors of recurrence in resectable colorectal liver metastases: A systematic review and meta-analysis2026