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July 1, 2026Cancer Genomics & ProteomicsOpen Access

Integrative Genomic and Clinical Profiling of Colorectal Cancer Liver Metastases to Guide Personalized Surgery and Liver Transplantation

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Authors

DMDimitrios MorisBNBrian NguyenAKAlexander Kroemer

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Overview

Randomized trial reveals survival outcomes in colorectal cancer liver metastases, suggesting genomic profiling improves surgical decisions.

Key Points

  • This study aims to integrate genomic and clinical data to improve surgical and transplant decision-making for colorectal cancer liver metastases.
  • Analyzed 503 patients with liver-only metastatic colorectal cancer using genomic and clinical data from the Memorial Sloan Kettering cohort.
  • Assessed survival with Kaplan–Meier and Cox models and developed a molecular-risk classification.
  • Applied machine-learning models to predict 24-month mortality.
  • Molecular-risk groups showed significant differences in 5-year overall survival (OS): 74.5% low, 56.6% intermediate, and 49.8% high risk (p<0.001).
  • Intermediate and high-risk classifications were associated with worse survival (HR=1.71 and 2.60, respectively).
  • Integrated clinicogenomic models slightly improved predictive performance (AUROC 0.697), with BRAF mutation, tumor sidedness, and age as important factors.

Cite This Study

Moris et al. (2026) studied this question.

synapsesocial.com/papers/6a44af635cd2549c8bc44629https://doi.org/10.21873/cgp.20592
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic Factors in Colorectal Liver Metastases: An Exhaustive Review of the Literature and Future Prospectives2025
  2. 2Molecular profiling and patient selection for the multimodal approaches for patients with resectable colorectal liver metastases2024 · 5 citations
  3. 3New prognostic and predictive scoring systems for colorectal cancer liver metastases2026
  4. 4Abstract 4217: Multi-modal modeling of genomic, histopathologic, and lab data predicts survival after hepatectomy in oligometastatic colorectal cancer2026
  5. 5Critical Prognostic and Predictive Factors in Colorectal Liver Metastasis: A Thorough Analysis of Existing Literature and Future Outlook2026