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June 27, 2026PLoS ONEOpen Access

A tale of SARS-CoV-2 genomic surveillance in Mali: Variants introductions and transmission dynamics

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Authors

NKNoumou Yakhouba KeitaHOHarris OnyweraMAMahamadou Abdou

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Overview

Randomized trial uncovers variant introductions and transmission dynamics in Mali, suggesting continued virus monitoring is essential.

Key Points

  • This study aims to reconstruct the genomic landscape of SARS-CoV-2 in Mali from 2020 to 2023.
  • Analyzed 548 Malian sequences for variant tracking and lineage assignment.
  • High-quality subset of 305 sequences was used for transmission dynamics alongside 142 global genomes.
  • Conducted time-resolved phylogenetic reconstruction and molecular clock analyses using TreeTime v0.11.4.
  • Identified five epidemic waves driven by variant succession, from early 2020 to dominant XBB sublineages in 2023.
  • Estimated substitution rate at 1.56 x 10−3 substitutions per site per year, consistent with global trends.
  • Revealed high genetic variability in the spike gene, particularly in the receptor-binding domain.

Cite This Study

Keita et al. (2026) studied this question.

synapsesocial.com/papers/6a3f69caaea7db3c19540865https://doi.org/10.1371/journal.pone.0352020
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