Key result
Aspirin use is not linked to severe loss of intrinsic capacity in older adults.
Why the study?
The connection between aspirin use, alone or with ACEI/ARBs, and decline in intrinsic capacity or its subdomains among community-dwelling older adults was not well characterized.
Does aspirin use, alone or in combination with ACEI/ARBs, prevent the decline of intrinsic capacity in community-dwelling older adults?
Cross-Sectional (n=250)
No
Does aspirin use, alone or in combination with ACEI/ARBs, prevent the decline of intrinsic capacity in community-dwelling older adults?
Aspirin use alone does not protect against intrinsic capacity decline in older adults and may be associated with sensory impairment, though co-administration with ACEI/ARBs might offer a synergistic protective effect.
Answers are grounded in this paper and cite their sources.
No significant aspirin link to severe intrinsic capacity loss; leaves open sensory associations for prospective confirmation.
Background This study examines the connection between the substantial reduction in intrinsic capacity (IC) and unfavorable outcomes across a number of IC subdomains among older adults living in Chinese communities and the use of aspirin, both alone and in combination with angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI or ARBs). Methods A 1:1 closest-neighbor propensity score matching (PSM) strategy was used to reduce baseline confounding factors across aspirin users and non-users using cross-sectional data from the Lianyungang ICOPE pilot trial. Multivariate logistic regression analysis was used to evaluate the relationship between aspirin use and a significant deterioration in IC as well as unfavorable outcomes in several IC subdomains (sensory, physical, neuropsychiatric, and nutritional function). Results A total of 250 participants were analyzed after propensity score matching. The likelihood of a severe loss of intrinsic capacity was not substantially correlated with aspirin use alone (adjusted odds ratio [OR] = 1.54, 95% confidence interval [CI]: 0.88–2.71, p = 0.134). However, aspirin use was strongly linked to negative outcomes in sensory function, including very poor vision (adjusted OR = 2.95, 95% CI: 1.10–7.94, p = 0.032), poor hearing (adjusted OR = 3.21, 95% CI: 1.29–7.97, p = 0.012), and very poor hearing (adjusted OR = 2.08, 95% CI: 1.02–4.24, p = 0.045), all of which were statistically significant ( p < 0.05). Conclusion Aspirin use was not significantly correlated with negative outcomes in the categories of nutritional function, neuropsychiatry, or physical health. The incidence of severe loss of intrinsic ability was significantly reduced when aspirin was used in conjunction with angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARBs) ( p < 0.05). Furthermore, there was a sex variability in the relationship between aspirin use and sensory function-related outcomes.
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Wang et al. (2026) conducted a cross-sectional in Decline in intrinsic capacity (n=250). Aspirin use vs. Non-users was evaluated on Severe loss of intrinsic capacity (IC score ≥ 4) (adjusted OR 1.54, 95% CI 0.88-2.71, p=0.134). Aspirin use alone was not associated with a severe loss of intrinsic capacity in community-dwelling older adults.
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