Key result
Severely elevated triglycerides linked to ~52% higher maximum wall shear stress in the internal carotid artery.
Why the study?
Hypertriglyceridemia is a key cardiovascular risk factor, but the relationship between triglycerides and carotid hemodynamics in low-risk populations remains unclear.
Are elevated triglyceride levels associated with altered carotid hemodynamic parameters in patients with low cardiovascular risk?
Cross-Sectional (n=106)
No
Are elevated triglyceride levels associated with altered carotid hemodynamic parameters in patients with low cardiovascular risk?
Answers are grounded in this paper and cite their sources.
Severely elevated triglyceride levels are independently associated with increased wall shear stress in the carotid arteries of young, low-risk individuals, suggesting early hemodynamic alterations prior to overt cardiovascular disease.
Introduction Cardiovascular disease (CVD) remains a global health challenge, with hypertriglyceridemia as a key risk factor. The relationship between triglycerides (TG) and carotid hemodynamics in low-risk populations is unclear. Materials and methods This prospective study enrolled 180 participants aged 55 years or younger with low cardiovascular risk. Participants were divided into three groups based on TG levels: normal TG (<1.7 mmol/L), elevated TG (1.7–5.64 mmol/L), and severely elevated TG (≥5.65 mmol/L). 4D Flow MRI data were acquired using a 3 T MRI scanner, and hemodynamic parameters were measured. Statistical analysis included the Mann–Whitney U -test, Kruskal–Wallis H -test, ANOVA, mixed-effects models, and multiple linear regression. Results A total of 106 participants (mean age 37.05 ± 8.17 years, 62 males) were included. Significant differences in WSS-related parameters, particularly WSSmax and WSSmean, were observed across TG groups. In the RICA-1 segment, for normal TG, WSSmax (0.29 ± 0.10 Pa) and WSSmean (0.20 ± 0.06 Pa) were similar to those in the elevated TG group (WSSmax: 0.29 ± 0.10 Pa, WSSmean: 0.20 ± 0.06 Pa). In the severely elevated TG group, WSSmax (0.44 ± 0.14 Pa) and WSSmean (0.28 ± 0.08 Pa) were significantly higher than in the other groups ( p < 0.001). Similar differences were observed in the LICA-1 segment. In mixed-effects models adjusting for age, sex, total cholesterol, HDL-C, BMI, and smoking status, TG remained independently associated with WSSmax (B = 0.010, p < 0.001) and WSSmean (B = 0.004, p = 0.004). Conclusion Our study demonstrates that TG levels are independently associated with carotid WSS parameters after comprehensive covariate adjustment, with the most pronounced changes in the ICA-1 region among individuals with severely elevated TG. Clinical Trial Registration https://www.chictr.org.cn/showprojEN.html?proj=224462 , ChiCTR2400082465.
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Wang et al. (2026) conducted a cross-sectional in Hypertriglyceridemia in low cardiovascular risk (n=106). Severely elevated triglycerides (≥ 5.65 mmol/L) vs. Normal triglycerides (<1.7 mmol/L) was evaluated on Maximum wall shear stress (WSSmax) in the RICA-1 segment (p=<0.001). Severely elevated triglyceride levels were independently associated with higher maximum wall shear stress in the proximal internal carotid artery compared to normal levels.
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