Key result
Fasting hypertriglyceridaemia increases carotid intima-media thickness and impairs coronary microvascular functions in non-obese middle-aged women, but not in men.
Why the study?
Does fasting hypertriglyceridaemia increase carotid intima-media thickness and impair coronary flow reserve in otherwise healthy non-obese middle-aged adults?
Population
92 non-obese middle-aged adults, comprising 46 patients with fasting hypertriglyceridaemia and 46 healthy…
Comparison
Fasting hypertriglyceridaemia vs Normal cholesterol and triglyceride concentrations
Design
Case-control
Authors
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May indicate sex-specific subclinical risk in women; hypothesis-generating, needs prospective validation before practice change.
Observational (n=92)
Does fasting hypertriglyceridaemia increase carotid intima-media thickness and impair coronary flow reserve in otherwise healthy non-obese middle-aged adults?
Fasting hypertriglyceridaemia is associated with subclinical atherosclerosis and impaired coronary microvascular function specifically in non-obese middle-aged women, suggesting a sex-specific cardiovascular risk profile.
Doğan Erdoğan (2006) conducted an observational in Hypertriglyceridaemia (n=92). Hypertriglyceridaemia vs. Normal triglyceride concentration was evaluated on Carotid intima-media thickness (IMT) and coronary flow reserve (CFR). Fasting hypertriglyceridaemia increases carotid intima-media thickness and impairs coronary microvascular functions in non-obese middle-aged women, but not in men.
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