Key result
Mild-to-moderate hypertriglyceridemia is linked to impaired flow-mediated vasodilation and higher ADMA levels in young men.
Why the study?
The mechanisms linking hypertriglyceridemia to coronary heart disease risk remain undefined, and prior studies examining the effects of chronic hypertriglyceridemia on endothelial function have yielded inconsistent results.
Is mild-to-moderate hypertriglyceridemia associated with impaired endothelial function, increased common carotid intima-media thickness, and elevated plasma asymmetric dimethylarginine in healthy young men?
Case-Control (n=30)
Is mild-to-moderate hypertriglyceridemia associated with impaired endothelial function, increased common carotid intima-media thickness, and elevated plasma asymmetric dimethylarginine in healthy young men?
Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and elevated plasma asymmetric dimethylarginine prior to any detectable increase in carotid intima-media thickness.
Answers are grounded in this paper and cite their sources.
May indicate early endothelial impairment in mild hypertriglyceridemia; hypothesis-generating and should not change practice.
OBJECTIVES: The aim of this study was to investigate endothelial function and common carotid intima-media thickness (IMT) in healthy young men with mild-to-moderate hypertriglyceridemia. Plasma asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, was measured to further elucidate the mechanisms involved. BACKGROUND: Hypertriglyceridemia is a risk factor for coronary heart disease although the mechanisms behind the increased risk remain to be defined. Acute elevation of plasma triglycerides induced by an intravenous fat load is associated with impaired endothelial function. The results of studies examining acute effects induced by a high-fat meal or effects of chronic hypertriglyceridemia on endothelial function are more inconsistent. METHODS: Flow-mediated vasodilation and nitroglycerin-induced vasodilation of the brachial artery and common carotid IMT were measured noninvasively by ultrasound technique in 15 hypertriglyceridemic (HTG) subjects and 15 matched controls, mean age 34 years. Plasma concentrations of ADMA were measured by high-performance liquid chromatography. RESULTS: Flow-mediated vasodilation was decreased in the HTG group (p < 0.0001), whereas nitroglycerin-induced vasodilation and carotid IMT did not differ significantly. Asymmetric dimethylarginine concentrations were higher in the HTG group (p < 0.05). CONCLUSIONS: Hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentration of ADMA but not with increased IMT of the common carotid artery. The corollary is that chronic hypertriglyceridemia results in endothelial dysfunction, possibly due to increased ADMA concentration, and that endothelial dysfunction might precede increased IMT among the early manifestations of atherosclerosis.
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Lundman et al. (2001) conducted a case-control in Mild-to-moderate hypertriglyceridemia (n=30). Mild-to-moderate hypertriglyceridemia vs. Matched healthy normotriglyceridemic controls was evaluated on Brachial artery flow-mediated vasodilation, common carotid intima-media thickness (IMT), and plasma asymmetric dimethylarginine (ADMA) concentrations (p=<0.0001). Mild-to-moderate hypertriglyceridemia in young men was associated with decreased flow-mediated vasodilation and higher plasma ADMA concentrations compared with controls.
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