Key result
Childhood hypercholesterolemia is linked to ~30% greater carotid IMT and elevated plasma ADMA levels.
Why the study?
The relationship of carotid intima-media thickness and endothelial function parameters such as plasma ADMA and homocysteine levels with hypercholesterolemia in children was not well characterized.
Do hypercholesterolemic children have increased carotid intima-media thickness and altered endothelial function parameters compared to healthy controls?
Cross-Sectional (n=94)
No
Do hypercholesterolemic children have increased carotid intima-media thickness and altered endothelial function parameters compared to healthy controls?
Absolute Event Rate: 0.682% vs 0.523%
p-value: p=<0.01
Plasma ADMA levels and carotid IMT are elevated in hypercholesterolemic children and may serve as early indicators of atherosclerosis.
May signal early vascular changes in hypercholesterolemic children; hypothesis-generating and requires longitudinal validation before clinical adoption.
The aim of this study was to examine the intima-media thickness (IMT) of carotid arteries and endothelial function parameters such as plasma asymmetric dimethylarginine (ADMA) and homocysteine levels in hypercholesterolemic children and to investigate the relations of these parameters with hypercholesterolemia. Fifty-seven hypercholesterolemic and 37 healthy children were included in the study. Hypercholesterolemia was defined as 155 mg/dl and above for low-density lipoprotein (LDL)-cholesterol. Plasma concentrations of ADMA and homocysteine were measured and the measurement of carotid IMT was determined. Both carotid IMT and plasma ADMA levels were significantly higher in hypercholesterolemic children than healthy children (p<0.01). No significant difference was determined in homocysteine concentration between hypercholesterolemic children and the control group (p>0.05). No significant correlation was observed between lipid profiles and the levels of ADMA and homocysteine. However, a significant positive correlation was found between carotid IMT and total and LDL-cholesterol levels and between the levels of ADMA and LDL-cholesterol. In conclusion, the progressive increase in ADMA levels and carotid IMT and the positive relationship between carotid IMT and serum cholesterol levels support that plasma ADMA levels and carotid IMT can be indicators of early atherosclerosis in hypercholesterolemic children.
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Hasanoğlu et al. (2011) conducted a cross-sectional in Hypercholesterolemia (n=94). Hypercholesterolemia vs. Healthy normocholesterolemic children was evaluated on Mean carotid intima-media thickness (IMT) (p=<0.01). Hypercholesterolemic children had significantly higher mean carotid intima-media thickness (0.682 mm vs 0.523 mm) and plasma ADMA levels compared to healthy controls (p<0.01).
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