Higher baseline TyG_CVAI was associated with an increased risk of first stroke (HR 1.40; 95% CI 1.15-1.71), but this predictive capacity was attenuated in individuals with diabetes.
Cohort (n=7,744)
Yes
Does a higher TyG_CVAI predict incident stroke in individuals with different glycemic metabolic states?
Elevated TyG_CVAI is a significant predictor of incident stroke in middle-aged and older adults with normal glucose regulation or prediabetes, but its predictive value is attenuated in those with diabetes.
Hazard Ratio: 1.4 (95% CI 1.15–1.71)
p-value: p=<.001
The triglyceride-glucose-Chinese visceral adiposity index (TyGCVAI) has been validated as an effective predictor of early stroke. However, its predictive efficacy across different glycemic metabolic states remains unexplored. This study utilized data from the China Health and Retirement Longitudinal Study, including 7744 stroke-free participants. Participants were categorized into 3 glycemic groups: diabetes mellitus (DM), prediabetes mellitus (Pre-DM), and normal glucose regulation (NGR). K-means clustering further divided participants into 2 clusters based on TyGCVAI fluctuations: Cluster 1 (lower TyGCVAI) and Cluster 2 (higher TyGCVAI). The primary outcome was the first stroke occurrence. Statistical analyses included Kaplan–Meier survival curves, Cox proportional hazards models, restricted cubic spline analysis, and receiver operating characteristic curve analysis to assess associations between baseline TyGCVAI and stroke risk. Over 9 years (2011–2020), 540 participants (7. 0%) experienced a first stroke. Participants in Cluster 2 (higher TyGCVAI) exhibited a significantly elevated stroke risk compared to Cluster 1. Kaplan–Meier analysis revealed significant differences in stroke incidence between clusters among Pre-DM, NGR, and the overall population (P. 1). Restricted cubic spline analysis further supported that higher TyGCVAI levels correlated with increased stroke risk. Elevated baseline TyGCVAI is significantly associated with stroke risk in middle-aged and older adults. However, its predictive capacity is attenuated in individuals with diabetes compared to those with normal glycemic metabolism. These findings underscore the importance of considering glycemic status when evaluating TyGCVAI as a stroke predictor.
Huang et al. (Fri,) conducted a cohort in Incident stroke (n=7,744). Higher TyG_CVAI (Cluster 2) vs. Lower TyG_CVAI (Cluster 1) was evaluated on first stroke occurrence (HR 1.40, 95% CI 1.15-1.71, p=<.001). Higher baseline TyG_CVAI was associated with an increased risk of first stroke (HR 1.40; 95% CI 1.15-1.71), but this predictive capacity was attenuated in individuals with diabetes.