Higher Pre-AF sub-class was associated with higher NT-pro BNP (84.0 vs 186.1 vs 558.2 ng/L, p<0.001) and larger left atrial volume, but not specifically with incident AF diagnosis.
Cohort (n=254)
Does sub-classification of Pre-AF using structural, electrical, and biomarker parameters predict major adverse events in individuals at high risk of developing AF?
Sub-classification of Pre-AF using multi-modal parameters has prognostic implications but does not specifically predict incident AF diagnosis in routine care.
BACKGROUND: A Pre-atrial fibrillation (Pre-AF) status has been postulated to exist when there are structural or electrical findings predisposing to AF, but it is not well described in relation to prognosis. OBJECTIVES: This prospective cohort study aims to sub-classify Pre-AF by structural, electrical and biomarker parameters and quantify associations with major adverse events. METHODS: Prospective cohort study of individuals with high risk of developing AF (according to the FIND-AF risk score), who underwent echocardiographic, ECG and biomarker assessment. Pre-AF sub-classes were specified as follows: Pre-AF 1 (one of echocardiographic, ECG or biomarker parameters); Pre-AF 2 (two parameters); and Pre-AF 3 (three parameters). Individuals were followed up for a composite primary outcome of major adverse cardiovascular, cerebrovascular and cognitive events (incident AF, heart failure, ischaemic stroke/TIA, myocardial infarction, dementia or cardiovascular death). RESULTS: Of 254 participants (mean age 74.9 (+/- 5.8) years, 50% women), 82 (32.3%) were classified as Pre-AF 1, 90 (35.4%) as Pre-AF 2, and 82 (32.3%) as Pre-AF 3. Higher Pre-AF sub-class was associated with higher NT-pro BNP (84.0 ng/L vs 186.1 ng/L vs 558.2 ng/L, p<0.001) and larger left atrial volume (29.0 ml/m CONCLUSIONS: Sub-classification of Pre-AF using ECG, echocardiography and NT-proBNP has prognostic implications but is not specifically associated with diagnosis of incident AF in routine care.
Wahab et al. (Mon,) conducted a cohort in Pre-atrial fibrillation (Pre-AF) (n=254). Pre-AF sub-classes (Pre-AF 1, 2, and 3) vs. Lower Pre-AF sub-classes was evaluated on Composite of major adverse cardiovascular, cerebrovascular and cognitive events (incident AF, heart failure, ischaemic stroke/TIA, myocardial infarction, dementia or cardiovascular death). Higher Pre-AF sub-class was associated with higher NT-pro BNP (84.0 vs 186.1 vs 558.2 ng/L, p<0.001) and larger left atrial volume, but not specifically with incident AF diagnosis.