Key result
Pediatric patients with healing-stage acute myocarditis had significantly higher ICAM-1 expression on myocardial tissue compared to controls (81% vs 24%, P<0.01).
Population
11 pediatric patients with biopsy-proven myocarditis or cardiomyopathy providing 31 biopsy specimens.
Design
Case-control
Authors
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ICAM-1 expression may support myocarditis evaluation in children; leaves open validation as a diagnostic biomarker.
Observational (n=11)
Absolute Event Rate: 81% vs 24%
p-value: p=<0.01
Persistent expression of ICAM-1 and VCAM-1 in pediatric myocarditis suggests ongoing immunological myocardial cell damage and may serve as a diagnostic marker.
T Ino (1997) conducted an observational in Lymphocytic myocarditis and cardiomyopathy (n=11). Acute myocarditis vs. Control specimens from right ventricular muscle resected for tetralogy of Fallot was evaluated on Expression of ICAM-1 on myocardial tissue (p=<0.01). Pediatric patients with healing-stage acute myocarditis had significantly higher ICAM-1 expression on myocardial tissue compared to controls (81% vs 24%, P<0.01).
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