March 1, 1992The American Journal of Surgical Pathology
Pleomorphic Malignant Fibrous Histiocytoma
Key result
Pathological reassessment of 159 tumors diagnosed as pleomorphic sarcomas revealed that 63% were specific sarcomas other than MFH, suggesting pleomorphic MFH is a meaningless diagnosis.
Population
159 tumors previously diagnosed as pleomorphic sarcomas
Design
Case_series
Authors
Discussion
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Member takes
Implication
Questions pleomorphic MFH as a default diagnosis; leaves open standardized reclassification of pleomorphic sarcomas.
Study Design
Type
Observational (n=159)
Structured PICO
P
Population
159 tumors previously diagnosed as pleomorphic sarcomas reassessed morphologically, immunohistochemically, and ultrastructurally.
E
Exposure
Morphological, immunohistochemical, and ultrastructural reassessment
O
Outcome
Validity of pleomorphic malignant fibrous histiocytoma (MFH) diagnosis and specific tumor classification
Pleomorphic malignant fibrous histiocytoma is likely a meaningless diagnosis of convenience representing a heterogeneous group of poorly differentiated neoplasms, rather than a distinct entity.
Limitations
- 21 of the unclassifiable cases were either small biopsies or subtotally necrotic
Cite This Study
Christopher D.�M. Fletcher (1992) conducted an observational in Pleomorphic malignant fibrous histiocytoma (n=159). Pathological reassessment was evaluated on Tumor reclassification. Pathological reassessment of 159 tumors diagnosed as pleomorphic sarcomas revealed that 63% were specific sarcomas other than MFH, suggesting pleomorphic MFH is a meaningless diagnosis.