Key result
Bupropion did not adversely affect ejection fraction and avoided the severe orthostatic hypotension that required discontinuation in 50% of patients taking imipramine.
Authors
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Bupropion may be preferred over imipramine for depression in heart failure; confirms ejection fraction safety while avoiding orthostatic hypotension.
RCT (n=10)
double-blind
random crossover
Absolute Event Rate: 0% vs 50%
Roose et al. (1987) conducted an RCT in Depression with congestive heart failure (n=10). Bupropion vs. Imipramine was evaluated on Severe orthostatic hypotension requiring discontinuation of drug. Bupropion did not adversely affect ejection fraction and avoided the severe orthostatic hypotension that required discontinuation in 50% of patients taking imipramine.
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