Key result
Imipramine did not impair resting ejection fraction but caused severe orthostatic hypotension requiring discontinuation in 7 of 15 depressed patients with left ventricular dysfunction.
Why the study?
Does imipramine affect left ventricular performance or cause adverse events in depressed patients with congestive heart failure?
Population
15 depressed patients with notable preexisting left ventricular dysfunction (congestive heart failure)
Design
Case_series
Authors
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Warrants orthostatic monitoring with imipramine in LV dysfunction; leaves open its cardiac safety in controlled trials.
Observational (n=15)
Does imipramine affect left ventricular performance or cause adverse events in depressed patients with congestive heart failure?
While imipramine does not further impair resting left ventricular performance in depressed patients with heart failure, it carries a high risk of severe orthostatic hypotension requiring careful monitoring.
Alexander H. Glassman (1983) conducted an observational in Depression with congestive heart failure (n=15). Imipramine hydrochloride vs. Baseline (before treatment) was evaluated on Ejection fraction at rest. Imipramine did not impair resting ejection fraction but caused severe orthostatic hypotension requiring discontinuation in 7 of 15 depressed patients with left ventricular dysfunction.
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