Key result
Major adverse reactions interrupting desipramine therapy were more frequent in patients over 60 years old (39%) and those receiving antipsychotics (32%), but unrelated to plasma concentrations.
Why the study?
What clinical variables and plasma concentrations are associated with major adverse reactions interrupting desipramine therapy?
Population
84 patients treated with desipramine hydrochloride
Design
Cohort
Authors
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Age >60 and antipsychotic co-use linked to more desipramine discontinuations; hypothesis-generating and should not yet change practice.
Observational (n=84)
What clinical variables and plasma concentrations are associated with major adverse reactions interrupting desipramine therapy?
Major adverse reactions to desipramine are more strongly associated with advanced age and concurrent antipsychotic use than with plasma drug concentrations.
J. Craig Nelson (1982) conducted an observational in Patients receiving desipramine treatment (n=84). Desipramine hydrochloride was evaluated on Major adverse reactions interrupting drug therapy. Major adverse reactions interrupting desipramine therapy were more frequent in patients over 60 years old (39%) and those receiving antipsychotics (32%), but unrelated to plasma concentrations.
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