Population
Anaesthetized rats
Design
Preclinical
Follow-up
During infusion
Authors
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Desipramine may carry greater cardiotoxicity risk than protriptyline; leaves open human relevance and should not yet change practice.
In a rat model, desipramine demonstrated greater cardiotoxicity than protriptyline, affecting heart rate and atrioventricular conduction at lower plasma concentrations.
Bianchetti et al. (1977) studied this question.
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