Why the study?
Do plasma levels of imipramine correlate with adverse cardiovascular effects in prepubertal depressed children?
Population
22 prepubertal depressed children
Design
Cohort
Authors
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May support level-guided dosing to limit effects in children; extends adult data but leaves open need for prospective trials.
Do plasma levels of imipramine correlate with adverse cardiovascular effects in prepubertal depressed children?
In prepubertal children treated with imipramine, plasma levels exceeding 225 ng/ml are associated with cardiovascular adverse effects, warranting close monitoring.
Preskorn et al. (1983) studied this question.
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