Why the study?
Does imipramine treatment at doses of 3.5 mg/kg or more increase PR interval in children?
Does imipramine treatment at doses of 3.5 mg/kg or more increase PR interval in children?
Imipramine at doses of 3.5 mg/kg or more in children is associated with PR interval prolongation, warranting routine EKG monitoring.
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May warrant ECG caution at imipramine ≥3.5 mg/kg in children; leaves open prospective validation of monitoring.
There are increasing reports of serious side effects in children with clinical use of imipramine in high doses. Our analysis of the EKG effects of imipramine in 25 hyperactive and 8 school phobic children suggests that children on a dose of imipramine of 3.5 mg/kg or more are likely to show an increase in PR interval of .02 seconds or more and that such increases are more likely to occur in patients with a small pretreatment PR interval. In 7 children the PR interval prolongation was above the rate-corrected norm. EKG monitoring seems desirable in children maintained on imipramine dose of 3.5 mg/kg or more.
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Saraf et al. (1978) studied this question.
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