Why the study?
Does imipramine at doses of 25 to 75 mg cause EKG changes in children with normal cardiovascular function treated for enuresis?
Does imipramine at doses of 25 to 75 mg cause EKG changes in children with normal cardiovascular function treated for enuresis?
Therapeutic doses of imipramine (25-75 mg) do not cause substantial EKG changes in enuretic children with normal baseline cardiovascular function, suggesting routine EKG monitoring may only be necessary at higher doses.
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May support limiting routine EKG monitoring to higher doses; leaves open questions in cardiac-risk children.
The authors studied the monthly electrocardiographic tracings of 27 children with normal cardiovascular function receiving imipramine therapy for enuresis. They found no substantial EKG changes in any of these children, who were receiving doses of 25 to 75 mg of the drug. They conclude that electrocardiographic monitoring may be essential only when more than 25 to 75 mg of imipramine is given and that it should be established that the patient's cardiovascular function is normal before the drug is administered.
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Martin et al. (1975) studied this question.
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