Imipramine in Enuresis—psychological and Physiological Effects

Summary Imipramine was given in a single nocturnal dose of 50 mg to 24 mostly psychiatrically normal, enuretic boys for three weeks in a double‐blind, placebo‐controlled, crossover trial to determine what effects the drug was having on systems other than the urinary tract. Behavioural changes, mostly of a positive kind, slight weight loss, tachycardia, raised diastolic blood pressure and cognitivie changes occurred, suggesting that the effect of the drug in children is analogous to that of the stimulants, at least over a three week period. This would also suggest that the effect of anti‐depressants in normal subjects is no different from that in depressed patients, though the findings of this study require replication.