Children with bicuspid aortic valve had significantly impaired aortic elastic properties, including lower aortic strain (14.79 vs 21.03) and distensibility compared to healthy controls (p<0.001).
Case-Control (n=80)
Do children with bicuspid aortic valve have impaired aortic elastic properties and altered circulating matrix biomarkers compared to healthy controls?
In children with bicuspid aortic valve, impaired aortic biomechanics and extracellular matrix remodeling are detectable before overt aortic dilatation or myocardial dysfunction.
Absolute Event Rate: 14.79% vs 21.03%
p-value: p=<0.001
Abstract Background Bicuspid aortic valve (BAV) is associated with early aortopathy that may precede overt aortic dilatation. Functional assessment of aortic biomechanics and extracellular matrix (ECM) biomarkers may provide additional insight beyond conventional diameter-based evaluation. Methods In this prospective case–control study, 40 children with BAV and 40 healthy controls underwent echocardiographic assessment of ascending aortic elastic properties and left ventricular global longitudinal strain (GLS). ECM-related biomarkers were measured using ELISA. Results Children with BAV demonstrated significantly impaired aortic elastic properties, including lower aortic strain (14.79 ± 2.41 vs 21.03 ± 2.94) and distensibility (2.3 2.0–3.15 vs 4.7 4.1–5.7 ×10⁻³ mmHg⁻¹, p 0.05). Ascending aortic Z-scores were significantly higher in the BAV group. Serum MMP-2, MMP-9, and MMP-2/TIMP-1 ratio levels were elevated in children with BAV and were associated with impaired aortic elastic parameters. TGF-β1 levels did not differ between groups but demonstrated modest correlations with aortic biomechanics within the BAV cohort. Conclusion In children with BAV, impaired aortic biomechanics and ECM remodeling appear to precede before overt myocardial dysfunction. Integrated functional imaging and biomarker assessment may enhance detection of BAV-related aortopathy. Impact Functional impairment of aortic biomechanics and extracellular matrix remodeling are detectable in children with bicuspid aortic valve before overt aortic dilatation or myocardial dysfunction. This study integrates aortic strain–based functional imaging with circulating ECM biomarkers, providing pediatric evidence that biomechanical deterioration precedes structural aortopathy. Early functional aortic assessment may improve risk stratification and longitudinal surveillance strategies in pediatric patients with bicuspid aortic valve.
Şentürk et al. (Sat,) conducted a case-control in Bicuspid aortic valve (n=80). Bicuspid aortic valve vs. Healthy controls was evaluated on Aortic strain (p=<0.001). Children with bicuspid aortic valve had significantly impaired aortic elastic properties, including lower aortic strain (14.79 vs 21.03) and distensibility compared to healthy controls (p<0.001).