Key result
Children with bicuspid aortic valve exhibited significantly higher aortic stiffness index compared to healthy controls (3.8 vs 2.4, P < .0001).
Why the study?
The study aimed to determine aortic elasticity parameters and myocardial function in children with bicuspid aortic valve and to evaluate the effect of aortic leaflet phenotype and aortic dilatation on elasticity parameters.
Do children with bicuspid aortic valve have abnormal aortic elasticity and myocardial function compared to healthy children?
Case-Control (n=125)
Do children with bicuspid aortic valve have abnormal aortic elasticity and myocardial function compared to healthy children?
Absolute Event Rate: 3.8% vs 2.4%
p-value: p=<.0001
Children with bicuspid aortic valve exhibit abnormal aortic elasticity and myocardial function from infancy to adolescence, suggesting an intrinsic aortic wall abnormality independent of hemodynamics.
Early aortic stiffness and myocardial changes detectable in pediatric BAV; leaves open prognostic value and need for longitudinal studies.
BACKGROUND: The aim of the study was to determine the aortic elasticity parameters (EPs) and myocardial function in children with bicuspid aortic valve (BAV). Additionally, we evaluated the effect of aortic leaflet phenotype (ALP) and aortic dilatation on elasticity parameters. METHODS: Sixty-two children diagnosed with isolated BAV (mean age 9.3 years old; patient group) and 63 healthy children (control group) have been evaluated for this study. Patient group was divided into three age subgroups: between 0-6, 7-11 and 12-17 age intervals. Distensibility (DI) and stiffness index (SI) of ascending aorta were calculated by M-mode echocardiographic data. The myocardial functions were evaluated by tissue Doppler echocardiography. RESULTS: Patient group exhibited significantly lower DI and higher SI than control group (SI: 3.8 ± 1.7 vs 2.4 ± 0.8, P < .0001). The aortic elasticity indexes in patient group with different age subgroups were different from those in control subgroups. Patient group had significantly lower E' velocity at mitral lateral annulus and septum than control group (P < .017 and P < .001). There was no statistically significant correlation between E' velocities and DI/SI values. We, however, found a weak correlation between septal E' velocities and strain values (r = .255, P = .046). EP did not show statistically significant difference with regard to ALP and presence of aortic dilatation. CONCLUSION: Abnormality of aortic elasticity and myocardial functions can be detected in children with BAV from infantile to adolescent. Myocardial functions are not related to SI and DI. We considered the possibility of intrinsic aortic wall abnormality in children with BAV.
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Ekici et al. (2017) conducted a case-control in Bicuspid aortic valve (n=125). Bicuspid aortic valve vs. Healthy children was evaluated on Stiffness index (SI) of ascending aorta (p=<.0001). Children with bicuspid aortic valve exhibited significantly higher aortic stiffness index compared to healthy controls (3.8 vs 2.4, P < .0001).
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