Aortic stiffness parameters did not differ significantly between asymptomatic and symptomatic diastolic dysfunction groups, but E/E' values were significantly higher in the heart failure group (12.1 vs 10.0, p=0.014).
Cross-Sectional (n=75)
No
Do aortic stiffness parameters correlate with the progression from asymptomatic diastolic dysfunction to clinical diastolic heart failure in patients with preserved ejection fraction?
Aortic stiffness parameters do not directly differentiate asymptomatic diastolic dysfunction from clinical HFpEF, although they correlate with worsening diastolic function overall.
Absolute Event Rate: 12.1% vs 10%
p-value: p=0.014
Objective: This study aimed to explore a possible relationship between aortic stiffness parameters and diastolic function in patients with asymptomatic or symptomatic diastolic dysfunction, and subsequently, the effect of aortic stiffness parameters on the progression from asymptomatic diastolic dysfunction to clinical diastolic heart failure. Methods: Seventy-five subjects were enrolled in the study of whom 20 had diastolic heart failure with the left ventricle ejection fraction (LVEF) >50%, 20 had asymptomatic diastolic dysfunction with LVEF>50%, 16 had hypertension with normal diastolic function, and 19 were normotensive healthy subjects. Ascending aorta recordings for measuring aortic strain and distensibility as markers of aortic stiffness were obtained from a spot nearly 3 cm above the aortic valve using 2-D echocardiography under M-mode. Doppler echocardiography and 2-D echocardiographic measurements were used to determine diastolic function. Results: While no statistically significant difference in aortic strain or distensibility values was observed between the asymptomatic group and the diastolic heart failure group; however, E/E’ values were higher in the heart failure group 12.1 (10.0-17.1) vs. 10.0 (6.2-22.5) (p=0.014). Aortic strain and distensibility values significantly decreased as E/E’ values increased (r = −0.416; p < 0.001 and r = −0.576; p < 0.001, respectively) for pooled data from all groups. Conclusion: Although aortic stiffness parameters did not have a direct effect on the progression from asymptomatic diastolic dysfunction to diastolic heart failure, echocardiographic monitoring of these parameters may be beneficial in identifying patients who would progress to clinical heart failure from diastolic dysfunction.
Kuş et al. (Wed,) conducted a cross-sectional in Diastolic dysfunction and diastolic heart failure (n=75). Aortic stiffness and diastolic dysfunction vs. Asymptomatic diastolic dysfunction / Healthy controls was evaluated on E/E' ratio (p=0.014). Aortic stiffness parameters did not differ significantly between asymptomatic and symptomatic diastolic dysfunction groups, but E/E' values were significantly higher in the heart failure group (12.1 vs 10.0, p=0.014).