Key result
Decreased aortic distensibility on initial echocardiogram was significantly associated with the subsequent development of heart failure with preserved ejection fraction (OR 0.61).
Why the study?
Does increased aortic stiffness predict the development of HFpEF in patients with asymptomatic diastolic dysfunction?
Population
154 adults with asymptomatic diastolic dysfunction, matched for age, gender, race, and body surface area…
Comparison
Increased proximal aortic stiffness measured on… vs Normal or less proximal aortic stiffness
Design
Case-control
Authors
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May support echo-based risk stratification in diastolic dysfunction; hypothesis-generating for aortic stiffness as HFpEF predictor.
Case-Control (n=154)
No
Does increased aortic stiffness predict the development of HFpEF in patients with asymptomatic diastolic dysfunction?
Odds Ratio: 0.61 (95% CI 0.39–0.96)
Absolute Event Rate: 1.9% vs 2.8%
p-value: p=0.01
Increased proximal aortic stiffness on echocardiography precedes and predicts the development of HFpEF in patients with asymptomatic diastolic dysfunction.
Karagodin et al. (2017) conducted a case-control in Asymptomatic diastolic dysfunction (n=154). Aortic distensibility vs. Patients who remained free of heart failure was evaluated on Aortic distensibility (cm2dyne-1 10-3) (OR 0.61, 95% CI 0.39-0.96, p=0.01). Decreased aortic distensibility on initial echocardiogram was significantly associated with the subsequent development of heart failure with preserved ejection fraction (OR 0.61).
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