What question did this study set out to answer?

December 15, 2003HeartOpen Access

Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both

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Why the study?

Is aortic stiffness increased and associated with left ventricular diastolic dysfunction in patients with hypertension, diabetes, or both, without coronary artery disease?

Population

94 participants without coronary artery disease, including 25 with hypertension, 24 with diabetes, 18 with…

Comparison

Hypertension, diabetes, or both vs Healthy participants (n=27)

Design

Cross-sectional

Authors

MEMehmet ErenBarts Health NHS Trust

Discussion

Member takes

Implication

Hypothesis-generating for aortic stiffness in diastolic dysfunction; prospective studies needed before clinical adoption.

Key Points

To assess aortic elastic properties and evaluate their relationship with left ventricular diastolic function in patients with hypertension, diabetes, or both, in the absence of coronary artery disease.
Enrolled 94 participants without coronary artery disease into four cohorts: 27 healthy controls, 25 with hypertension, 24 with diabetes, and 18 with both conditions.
Calculated aortic strain and distensibility using echocardiographic aortic diameter measurements and sphygmomanometric blood pressure.
Performed multivariate regression analysis to assess the association between aortic distensibility and left ventricular filling deceleration time.
Aortic strain was significantly lower in hypertensive (11 ± 7%), diabetic (9 ± 3%), and combined (8 ± 3%) groups compared to controls (18 ± 8%, p < 0.001).
Aortic distensibility was significantly impaired in hypertensive (3.1 ± 1.5), diabetic (5.1 ± 2.8), and combined (2.0 ± 0.9 cm²/dyn/10³) cohorts versus controls (10.0 ± 5.1 cm²/dyn/10³, p < 0.001).
Multivariate regression identified aortic distensibility as the variable most closely related to left ventricular deceleration time across the entire study population (standardized β = -0.48, p < 0.001, overall R² = 0.22).

Structured PICO

Is aortic stiffness increased and associated with left ventricular diastolic dysfunction in patients with hypertension, diabetes, or both, without coronary artery disease?

Population

94 participants without coronary artery disease, including 25 with hypertension, 24 with diabetes, 18 with both hypertension and diabetes, and 27 healthy controls.

Intervention

Hypertension, diabetes, or both (observational exposure)

Comparator

Healthy participants (n=27)

Outcome

Aortic strain and distensibility calculated from aortic diameters measured by echocardiography and blood pressure, and their relation to left ventricular diastolic function (deceleration time)surrogate

Aortic stiffness is increased in patients with hypertension and/or diabetes and is independently associated with left ventricular diastolic dysfunction, even in the absence of coronary artery disease.

Cite This Study

Mehmet Eren (2003) studied this question.

synapsesocial.com/papers/6a7ba00261c5163555c62333 https://doi.org/10.1136/heart.90.1.37

Topics

Hypertension management Echocardiography

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Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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