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June 29, 2026Fundamental and Clinical Pharmacology

Probucol Exerts Anticancer Effects on SW480 Human Colorectal Cancer Cells via Modulation of Apoptosis‐ and Angiogenesis‐Related Proteins

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Authors

EKEcem Kaya‐SezginerFBFiliz Bakar‐Ates

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Overview

Randomized trial evaluates probucol's anticancer effects in colorectal cancer cells, suggesting its potential as a multitarget therapeutic agent.

Key Points

  • The study aims to investigate the anticancer effects of probucol on SW480 human colorectal cancer cells and the related molecular mechanisms.
  • SW480 cells treated with probucol were analyzed via MTT assay.
  • Apoptosis assessed using Annexin V binding and multicaspase activity assays.
  • Protein expression evaluated by western blot and MMP-9 mRNA quantified by real-time PCR.
  • Probucol reduced cell viability in a dose-dependent manner and induced cell cycle arrest at G0/G1 phase.
  • Increased apoptotic populations were observed along with enhanced multicaspase activation.
  • Downregulation of Bcl-2 and upregulation of Bax were noted, alongside suppressed expression of VEGF, eNOS, and decreased MMP-9 mRNA.

Cite This Study

Kaya‐Sezginer et al. (2026) studied this question.

synapsesocial.com/papers/6a420b2ff91bb43ea9192483https://doi.org/10.1111/fcp.70104
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