Key result
Oral folic acid improves endothelium-dependent dilation by ~37% vs. placebo in hyperhomocysteinemia.
Why the study?
Does oral folic acid supplementation improve arterial endothelial function in asymptomatic adults with hyperhomocystinemia?
Population
17 asymptomatic adults with fasting total homocystine levels above 75th percentile and no history of…
Comparison
Oral folic acid 10 mg/day for 8 weeks vs Placebo for 8 weeks
Design
RCT, randomized crossover, double-blind, placebo-controlled
Follow-up
8 weeks per treatment period
Authors
Loading...
High-dose oral folic acid supplementation significantly improves brachial artery endothelial function and lowers homocysteine levels in asymptomatic adults with relative hyperhomocystinemia.
RCT (n=17)
Double-blind
Randomized
Does oral folic acid supplementation improve arterial endothelial function in asymptomatic adults with hyperhomocystinemia?
Absolute Event Rate: 8.2% vs 6%
p-value: p=<0.001
High-dose oral folic acid supplementation significantly improves brachial artery endothelial function and lowers homocysteine levels in asymptomatic adults with relative hyperhomocystinemia.
Woo et al. (1999) conducted an RCT in Hyperhomocystinemia (n=17). Folic acid vs. Placebo was evaluated on Flow-mediated endothelium-dependent dilation of the brachial artery (p=<0.001). Oral folic acid supplementation significantly improved endothelium-dependent dilation compared with placebo (8.2% vs. 6.0%; p<0.001) in asymptomatic adults with hyperhomocystinemia.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: