Key result
Each 5-point increase in the INTERHEART risk score was associated with a 9 mm3 increase in carotid wall volume (P<0.0001) and a 32% increase in silent brain infarction (95% CI 20-45%).
Why the study?
Cardiovascular risk factors guide primary prevention risk stratification, but whether simple cardiac risk scores are associated with MRI-detected subclinical cerebrovascular disease was unclear.
Does cardiovascular risk scoring predict MRI-detected subclinical cerebrovascular disease in adults without known CVD?
Cohort (n=7,594)
Does cardiovascular risk scoring predict MRI-detected subclinical cerebrovascular disease in adults without known CVD?
Effect estimate: 32% increase in SBI per 5-point increase in IHRS (95% CI 20-45)
p-value: p=<0.0001
Simple clinical cardiovascular risk scores (INTERHEART and Framingham) are significantly associated with MRI-detected subclinical cerebrovascular disease in asymptomatic adults.
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Risk scores may flag subclinical cerebrovascular disease for targeted prevention; extends prior associations but leaves causal impact on outcomes open.
Anand et al. (2019) conducted a cohort in No history of cardiovascular disease (n=7,594). INTERHEART risk score (IHRS) and Framingham Risk Score was evaluated on MRI-detected subclinical cerebrovascular disease including carotid wall volume (CWV), carotid intraplaque haemorrhage (IPH), and silent brain infarction (SBI) (32% increase in SBI per 5-point increase in IHRS, 95% CI 20-45, p=<0.0001). Each 5-point increase in the INTERHEART risk score was associated with a 9 mm3 increase in carotid wall volume (P<0.0001) and a 32% increase in silent brain infarction (95% CI 20-45%).
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