In post-MI patients with LVEF >30%, severe autonomic failure identified a high-risk group with a 5-year mortality rate of 38.6% compared to 6.1% in those without severe autonomic failure.
Cohort (n=2,343)
Does the combination of heart rate turbulence and deceleration capacity predict mortality in post-infarction patients with LVEF > 30%?
In post-MI patients with LVEF > 30%, severe autonomic failure assessed by Holter monitoring identifies a high-risk group with a mortality risk equivalent to patients with LVEF <= 30%.
Absolute Event Rate: 38.6% vs 6.1%
AIMS: To investigate the combination of heart rate turbulence (HRT) and deceleration capacity (DC) as risk predictors in post-infarction patients with left ventricular ejection fraction (LVEF) > 30%. METHODS AND RESULTS: We enrolled 2343 consecutive survivors of acute myocardial infarction (MI) ( or = 0%) and abnormal DC (30% (cumulative 5-year mortality rates of 37.9% and 7.8%, respectively). Among patients with LVEF > 30%, SAF identified another high-risk group of 117 patients with 37 deaths (cumulative 5-year mortality rates of 38.6% and 6.1%, respectively). Merging both high-risk groups (i.e. LVEF 30%, SAF identifies a high-risk group equivalent in size and mortality risk to patients with LVEF < or = 30%.
Bauer et al. (2008) conducted a cohort in acute myocardial infarction (n=2,343). Severe autonomic failure (abnormal heart rate turbulence and deceleration capacity) vs. Absence of severe autonomic failure was evaluated on All-cause, cardiac, and sudden cardiac mortality within the first 5 years of follow-up. In post-MI patients with LVEF >30%, severe autonomic failure identified a high-risk group with a 5-year mortality rate of 38.6% compared to 6.1% in those without severe autonomic failure.