Key result
In heart failure patients with LVEF >30%, an impaired heart rate turbulence slope was associated with an increased risk of arrhythmic events (HR 3.81; 95% CI 1.35-10.7; P=0.012).
Why the study?
Do autonomic markers predict cardiovascular and arrhythmic events in patients with symptomatic chronic heart failure?
Cohort (n=388)
Do autonomic markers predict cardiovascular and arrhythmic events in patients with symptomatic chronic heart failure?
Hazard Ratio: 3.81 (95% CI 1.35–10.7)
p-value: p=0.012
Autonomic indexes, particularly heart rate turbulence, provide independent predictive value for long-term cardiovascular and arrhythmic outcomes in heart failure patients, especially those with LVEF >30%.
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May refine arrhythmic risk stratification in HF with LVEF >30%; hypothesis-generating and requires prospective validation.
Rovere et al. (2012) conducted a cohort in symptomatic chronic heart failure (n=388). Impaired turbulence slope (<2.5 ms per RR interval) vs. Normal turbulence slope was evaluated on Cardiovascular mortality and combined sudden death + implantable cardioverter defibrillator discharge (HR 3.81, 95% CI 1.35-10.7, p=0.012). In heart failure patients with LVEF >30%, an impaired heart rate turbulence slope was associated with an increased risk of arrhythmic events (HR 3.81; 95% CI 1.35-10.7; P=0.012).
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