Indomethacin-induced scar thinning after experimental myocardial infarction.
Key result
Indomethacin administration early after experimental myocardial infarction resulted in marked scar thinning compared to saline (3.56 mm vs 7.24 mm; p<0.001).
Why the study?
Does indomethacin reduce scar thickness in dogs with experimental myocardial infarction?
Population
21 anesthetized, open-chest dogs with experimental myocardial infarction produced by occluding the left…
Comparison
Indomethacin 10 mg/kg i.v. given 15 minutes and… vs Saline given 15 minutes and 3 hours after…
Design
Preclinical
Follow-up
6 weeks
Authors
Discussion
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Member takes
Implication
Early NSAID use may thin post-MI scars clinically; leaves open human translation pending trials.
Structured PICO
Does indomethacin reduce scar thickness in dogs with experimental myocardial infarction?
P
Population
21 anesthetized, open-chest dogs with experimental myocardial infarction followed for 6 weeks.
I
Intervention
Indomethacin 10 mg/kg i.v. given 15 minutes and 3 hours after occlusion
C
Comparator
Saline given 15 minutes and 3 hours after occlusion
O
Outcome
Average thickness of the transmural scar and the noninfarcted left ventricular wall, and the ratio of the thickness of the transmural scar to the noninfarcted wall at 6 weekssurrogate
Main Result
Absolute Event Rate: 3.56% vs 7.24%
p-value: p=<0.001
Early administration of indomethacin after experimental myocardial infarction leads to marked scar thinning, which may have implications for post-MI remodeling and healing.
Cite This Study
Hammerman et al. (1983) studied Experimental myocardial infarction (n=21). Indomethacin vs. Saline was evaluated on Scar thickness (p=<0.001). Indomethacin administration early after experimental myocardial infarction resulted in marked scar thinning compared to saline (3.56 mm vs 7.24 mm; p<0.001).