Key result
Concomitant use of linezolid and meperidine resulted in serotonin syndrome in a 27-year-old man with acute leukemia.
Why the study?
Does concomitant treatment with linezolid and meperidine cause serotonin syndrome in a patient with acute leukemia?
Does concomitant treatment with linezolid and meperidine cause serotonin syndrome in a patient with acute leukemia?
Concomitant use of linezolid and meperidine can precipitate serotonin syndrome.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to monitor for serotonin syndrome with linezolid-meperidine; leaves open need for systematic safety studies.
Serotonin syndrome has been reported with administration of linezolid and serotonin reuptake inhibitors. Meperidine blocks the neuronal reuptake of serotonin. Serotonin syndrome after concomitant linezolid and meperidine therapy has not been described. We describe serotonin syndrome after concomitant use of linezolid and meperidine in a 27-year-old man with acute leukemia.
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Das et al. (2007) studied this question. Concomitant use of linezolid and meperidine resulted in serotonin syndrome in a 27-year-old man with acute leukemia.
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