Key result
Thrombus aspiration during primary percutaneous coronary intervention resulted in better TIMI 3 flow and faster ST-segment resolution compared with conventional angioplasty.
Why the study?
Does thrombus aspiration improve clinical and angiographic outcomes in patients with acute ST-elevation myocardial infarction undergoing primary PTCA?
Cohort (n=286)
Does thrombus aspiration improve clinical and angiographic outcomes in patients with acute ST-elevation myocardial infarction undergoing primary PTCA?
Thrombus aspiration during primary PCI for STEMI improves angiographic markers of reperfusion, including TIMI 3 flow and ST-segment resolution.
Supports thrombus aspiration in high-burden STEMI; extends RCT evidence for selective reperfusion benefit.
Thrombus exerts a major impact on the performance and outcome of primary and rescue interventions in acute ST-elevation myocardial infarction. Although the optimal treatment of thrombotic lesions is still controversial, thrombus aspiration provides an effective method to achieve successful reperfusion during primary angioplasty. We compared clinical and angiographic outcomes in 286 patients with acute ST-elevation myocardial infarction undergoing primary percutaneous transluminal coronary angioplasty (PTCA) and thrombus aspiration with those who underwent conventional PTCA without thrombus aspiration. Thrombus aspiration during primary percutaneous coronary intervention in patients with high thrombus burden resulted in better Thrombolysis in Myocardial Infarction (TIMI) 3 flow in the infarct-related artery and helped achieve faster ST-segment resolution on the electrocardiogram compared with conventional angioplasty without thrombus aspiration.
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Chacko et al. (2017) conducted a cohort in Acute ST-elevation myocardial infarction (n=286). Thrombus aspiration vs. Conventional PTCA without thrombus aspiration was evaluated on TIMI 3 flow and ST-segment resolution. Thrombus aspiration during primary percutaneous coronary intervention resulted in better TIMI 3 flow and faster ST-segment resolution compared with conventional angioplasty.
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