Thrombus Aspiration in ST-Segment–Elevation Myocardial Infarction
Why the study?
Does manual thrombus aspiration during PCI reduce cardiovascular mortality or increase stroke risk in patients with STEMI?
Population
19,047 patients with ST-segment-elevation myocardial infarction pooled from 3 large RCTs.
Comparison
Manual thrombus aspiration during percutaneous… vs Percutaneous coronary intervention (PCI) alone.
Design
Meta-analysis
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
Does not support routine thrombus aspiration in STEMI PCI; confirms neutral mortality effect with possible stroke increase.
Structured PICO
Does manual thrombus aspiration during PCI reduce cardiovascular mortality or increase stroke risk in patients with STEMI?
P
Population
19,047 patients (18,306 included in primary analysis) with ST-segment-elevation myocardial infarction (STEMI) pooled from 3 large RCTs (TAPAS, TASTE, and TOTAL).
I
Intervention
Manual thrombus aspiration during percutaneous coronary intervention (PCI).
C
Comparator
Percutaneous coronary intervention (PCI) alone.
O
Outcome
Cardiovascular mortality within 30 days (efficacy) and stroke or transient ischemic attack within 30 days (safety).hard clinical
Routine manual thrombus aspiration during PCI for STEMI does not significantly reduce cardiovascular mortality at 30 days and may increase the risk of stroke or transient ischemic attack.
Cite This Study
Jolly et al. (2016) studied this question.