Key result
Cardiac contractility modulation significantly increased median left ventricular ejection fraction from 30% to 39% and improved myocardial work parameters over 12 months in patients with heart failure and atrial fibrillation.
Why the study?
To evaluate the effect of cardiac contractility modulation on reverse remodeling and myocardial function measured by echocardiography in patients with chronic heart failure.
Does cardiac contractility modulation improve reverse remodeling and myocardial function in patients with chronic heart failure and atrial fibrillation?
Cohort (n=40)
No
Does cardiac contractility modulation improve reverse remodeling and myocardial function in patients with chronic heart failure and atrial fibrillation?
Absolute Event Rate: 39% vs 30%
p-value: p=0.000002
Cardiac contractility modulation therapy over 12 months significantly improves left ventricular ejection fraction and myocardial work efficiency in patients with chronic heart failure and atrial fibrillation.
CCM may improve LV remodeling in HF with AF; hypothesis-generating and requires randomized confirmation before practice change.
AIM: To study the effect of cardiac contractility modulation on reverse remodeling and myocardial function in patients with chronic heart failure (HF) according to echocardiography (EchoCG). MATERIALS AND METHODS: In a group of 40 patients with a combination of chronic HF and atrial fibrillation (AF), the dynamics of standard EchoCG parameters and the effectiveness of myocardial work of the left ventricle (LV) against the background of 12-month therapy of cardiac contractility modulation (CCM) were analyzed. RESULTS: The results obtained indicate a statistically significant positive effect of CCM on LV remodeling parameters and the effectiveness of myocardial work according to EchoCG. CONCLUSION: Transthoracic echocardiography is the main imaging method and provides great opportunities for evaluating the effectiveness of HF treatment, including non-drug methods such as CCM. Evaluation of LV myocardial function in patients with HF and implanted CCM devices is a promising scientific and practical research method.
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Сафиуллина et al. (2021) conducted a cohort in Chronic heart failure with atrial fibrillation (n=40). Cardiac contractility modulation (CCM) vs. Baseline (pre-implantation) was evaluated on Left ventricular ejection fraction (LVEF) (p=0.000002). Cardiac contractility modulation significantly increased median left ventricular ejection fraction from 30% to 39% and improved myocardial work parameters over 12 months in patients with heart failure and atrial fibrillation.
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