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February 17, 2021Russian Journal of CardiologyOpen Access

Dynamics of heart failure markers and cardiac reverse remodeling in patients receiving cardiac contractility modulation therapy

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Key result

Cardiac contractility modulation therapy in HFrEF patients was associated with decreased HF-related hospitalization rate (p<0.0001) and increased left ventricular ejection fraction (p<0.0001).

Why the study?

The clinical course and cardiac reverse remodeling in patients with HFrEF receiving cardiac contractility modulation therapy needed to be assessed.

Does cardiac contractility modulation therapy improve clinical outcomes and cardiac reverse remodeling in patients with HFrEF?

Comparison

CCM therapy compared by lead number, baseline LVEF, and HF etiology

Design

Cohort study

Follow-up

24 months

Authors

МВМ. А. ВандерELE. A. LyasnikovaLBL. A. Belyakova

Discussion

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Overview

May support CCM-associated remodeling in HFrEF; leaves open efficacy confirmation in RCTs.

Study Design

Type

Cohort (n=55)

Structured PICO

Does cardiac contractility modulation therapy improve clinical outcomes and cardiac reverse remodeling in patients with HFrEF?

P
Population
55 patients with NYHA class II-III HFrEF, sinus rhythm, and QRS<130 ms or QRS<150 ms of non-LBBB morphology receiving optimal medical therapy, followed for up to 24 months.
E
Exposure
Cardiac contractility modulation (CCM) therapy (device implantation)
O
Outcome
Clinical course and cardiac reverse remodeling (including hospitalizations and mortality due to decompensated HF, changes in HF class, NTproBNP concentration, peak oxygen consumption, six-minute walk test, left ventricular end-systolic and end-diastolic volumes, ejection fraction, and arrhythmias)

In patients with HFrEF and narrow QRS, cardiac contractility modulation therapy is associated with improved clinical status, reduced hospitalizations, and positive cardiac reverse remodeling over 24 months.

Cite This Study

Вандер et al. (2021) conducted a cohort in Heart failure with reduced ejection fraction (HFrEF) (n=55). Cardiac contractility modulation (CCM) therapy was evaluated on Hospitalizations and mortality due to decompensated HF, and changes in HF class, NTproBNP, peak oxygen consumption, and LVEF. Cardiac contractility modulation therapy in HFrEF patients was associated with decreased HF-related hospitalization rate (p<0.0001) and increased left ventricular ejection fraction (p<0.0001).

synapsesocial.com/papers/6a9399d8744b618ad237da14https://doi.org/10.15829/1560-4071-2021-4035
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HF Etiology and cardiac contractility modulation therapy2024
  2. 2Cardiac Contractility Modulation In Symptomatic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Single-Arm Meta-Analysis.2025
  3. 3CARDIAC CONTRACTILITY MODULATION IN SYMPTOMATIC HEART FAILURE WITH REDUCED EJECTION FRACTION: A SYSTEMATIC REVIEW AND SINGLE-ARM META-ANALYSIS2025
  4. 4Cardiac contractility modulation in heart failure with reduced ejection fraction treatment2022 · 3 citations
  5. 5USE OF CARDIAC CONTRACTILITY MODULATION: OUR EXPERIENCE2024