What type of study is this?

This is a Systematic Review study (also classified as: Meta-Analysis).

September 10, 2025Open Access

Cardiac Contractility Modulation in Symptomatic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Single-Arm Meta-Analysis

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Authors

RMR Motta CFChristian Fukunaga ESE. Silva

Discussion

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Overview

Systematic review and single-arm meta-analysis highlights improved functional capacity and quality of life in symptomatic heart failure patients, indicating potential benefits of cardiac contractility modulation.

Key Points

CCM therapy significantly improved six-minute walk test distance by an average of 44.96 meters in symptomatic HFrEF patients, enhancing exercise capacity.
Patients also experienced a notable reduction in NYHA functional class by an average of −0.89, indicating symptom relief after CCM therapy.
Quality of life improved significantly, with MLHFQ scores showing a mean decrease of 11.83 points, demonstrating the therapy’s positive impact on daily living.
Structural heart improvements included a 5.96% increase in LVEF and significant reductions in LVESV and LVEDV, supporting enhanced cardiac remodeling.

Cite This Study

Motta et al. (2025) studied this question.

synapsesocial.com/papers/68c188579b7b07f3a06123cd https://doi.org/10.22541/au.175692110.03294929/v1

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September 10, 2025Open Access

Cardiac Contractility Modulation in Symptomatic Heart Failure With Reduced Ejection Fraction: A Systematic Review and Single-Arm Meta-Analysis

View Full Paper

Ask AI

Bookmark

Authors

RMR Motta CFChristian Fukunaga ESE. Silva

Discussion

Member takes

Overview

Key Points

CCM therapy significantly improved six-minute walk test distance by an average of 44.96 meters in symptomatic HFrEF patients, enhancing exercise capacity.
Patients also experienced a notable reduction in NYHA functional class by an average of −0.89, indicating symptom relief after CCM therapy.
Quality of life improved significantly, with MLHFQ scores showing a mean decrease of 11.83 points, demonstrating the therapy’s positive impact on daily living.
Structural heart improvements included a 5.96% increase in LVEF and significant reductions in LVESV and LVEDV, supporting enhanced cardiac remodeling.

Cite This Study

Motta et al. (2025) studied this question.

synapsesocial.com/papers/68c188579b7b07f3a06123cd https://doi.org/10.22541/au.175692110.03294929/v1

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